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Hormonal Health

PT-141

PT-141 is a peptide studied for how it supports sexual desire — acting on the brain's pathways for arousal and emotional response, independent of hormonal systems.

It's used in protocols for men and women where desire has quieted despite everything else being in place.

Physician-Supervised
Licensed US Compounding Pharmacy
Third-Party Tested
Prescription-Only

Injection method

$206/month

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Charged only after your protocol is approved. Cancel anytime.

PT-141, also known as bremelanotide, is a synthetic melanocortin peptide — a class of compounds that acts on receptors in the brain involved in sexual response. Rather than affecting blood flow or hormone levels, it works in the central nervous system, on the pathways that shape sexual desire itself. It's used in men and women whose desire has quieted, particularly when other approaches haven't been the answer.

PT-141 is typically administered as a subcutaneous injection taken as needed, roughly 30 to 60 minutes before intimacy — not on a daily cycle like most SYNC protocols.

Your clinician sets your dose and how often it can be used based on your intake, and adjusts if you're not seeing what you should be.

Everything you need to inject at home, in one shipment:

The vial, lyophilized and ready to reconstitute
Bacteriostatic water for reconstitution
Insulin syringes
Alcohol prep pads
Step-by-step reconstitution and injection instructions in your care portal
Sharps disposal guidance

Every prescription is written by a US-licensed clinician after reviewing your intake. It's compounded at a licensed US 503A pharmacy held to cGMP manufacturing standards, and every batch is third-party tested for potency, sterility, pH balance, and endotoxins before it ships. Temperature-controlled from the pharmacy to your door. Full results in the Quality panel below.

Why PT-141

Restored Desire

Supports sexual desire and the wanting to be intimate.

Faster Responsiveness

Supports the body's arousal response and time to arousal.

Non-Hormonal Support

Acts on the nervous system rather than hormones or blood flow.

Emotional Connection

Supports the psychological side of intimacy and confidence with your partner.

Restored Desire

Supports sexual desire and the wanting to be intimate.

Faster Responsiveness

Supports the body's arousal response and time to arousal.

Non-Hormonal Support

Acts on the nervous system rather than hormones or blood flow.

Emotional Connection

Supports the psychological side of intimacy and confidence with your partner.

Restored Desire

Supports sexual desire and the wanting to be intimate.

Faster Responsiveness

Supports the body's arousal response and time to arousal.

Non-Hormonal Support

Acts on the nervous system rather than hormones or blood flow.

Emotional Connection

Supports the psychological side of intimacy and confidence with your partner.

Restored Desire

Supports sexual desire and the wanting to be intimate.

Faster Responsiveness

Supports the body's arousal response and time to arousal.

Non-Hormonal Support

Acts on the nervous system rather than hormones or blood flow.

Emotional Connection

Supports the psychological side of intimacy and confidence with your partner.

How it works

The path to your protocol.

From your intake to your door, every protocol is built by a licensed US clinician around who you are and where you're headed.

Take the assessment.

[01]

Your goals, your body, your history - everything your clinician needs to build a protocol around you.

Clinician-built protocol.

[02]

A US-licensed clinician reviews your intake, selects the right compound, dose and cycle, and approves your protocol within 24 hours.

Delivered. Then evolved.

[03]

Compounded at a licensed US pharmacy and shipped discreetly. Monthly check-ins keep your clinician close and your protocol evolving with you.

Start your protocol

Tested every batch. Independently.

Every SYNC protocol is compounded at a licensed US 503A pharmacy and third-party tested — every batch, against four pharmacopoeia standards. If a batch doesn't pass all four, it doesn't ship.

Potency

Passed

Confirms the vial contains what the label says — active ingredient within ±10% of prescribed concentration.

Sterility

Passed

Tested against USP 797 to confirm the compound is free from bacterial or fungal contamination.

pH balance

Passed

Balanced to minimise irritation at the injection site and remain compatible with the body.

Endotoxins

Passed

Tested against USP 85 to confirm bacterial endotoxin levels are within safe limits — protecting against fever and adverse reactions.

FROM THE COMMUNITY

The ones who stopped guessing

Excellent

"I've never had healthcare feel this frictionless. From the intake to messaging my clinician, everything just works - I ask a question, I get a real answer, and my protocol keeps moving. It's the kind of experience I wish more of healthcare felt like."

Jackson P.Metabolic protocol

"My cycle 2 protocol was genuinely different from cycle 1- the dose had been adjusted and one of the compounds swapped based on how I'd responded. It's the first time I've seen personalization actually happen, not just be marketed."

Chase H.Longevity protocol

"I'd done my research on peptides - the question wasn't whether to take them, it was who to trust. SYNC was the first place where the intake felt like actual medicine. My physician walked me through her reasoning before prescribing anything."

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

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Learn

The SYNC journal.

Physician-informed articles on the compounds, protocols and the research behind them.

SCIENCE

How to get peptides prescribed online: a step-by-step guide.

How to Get Peptides Prescribed Online (2026 Guide)

SAFETY

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HORMONAL

PT-141 (bremelanotide): how it works for men and women.

PT-141 (Bremelanotide): How It Works for Men and Women

View all articles

FAQ

Everything worth asking.

Protocols, prescriptions, and what happens after you order.

Contact our care team

Viagra and Cialis work on blood flow — they help the physical mechanics of arousal once desire is already there. PT-141 works differently: it acts on the central nervous system pathways involved in desire itself. It's used when the mechanics aren't the issue — when the wanting has quieted. Some people use PT-141 alongside vascular support like Viagra, but they answer different problems.

PT-141 is prescribed for adults noticing that sexual desire has quieted despite otherwise being in good health — in both men and women, typically from the mid-30s onward. It's commonly prescribed alongside TRT, HRT, ED medications, or other protocols. It's not appropriate for pregnancy, uncontrolled high blood pressure, or a history of cardiovascular events.

Most people tolerate PT-141 well. The most common is mild nausea in the first hour or two after injection — usually milder by the second or third use, which is why your clinician starts you at a low dose. Some people also notice mild flushing or an occasional headache, both typically passing within the hour. With repeated use, PT-141 can cause gradual changes in skin pigmentation — uncommon at the doses your clinician prescribes, and the monthly frequency limit exists to keep the risk low. Anything concerning — message us and we'll adjust.

PT-141 is typically taken 30 to 60 minutes before intimacy. Effects generally last several hours, though this varies by dose and individual response. It's not a daily medication — you use it when you plan to, not on a schedule. Your clinician sets how frequently it can be used based on your intake and how you respond.

The primary shift most people notice is desire returning — thinking about intimacy without needing a specific trigger, initiating more, feeling responsive. For most people this becomes clear within the first few uses.

Message us and we'll expedite a replacement — most reorders ship the same day. Your subscription is timed so this shouldn't happen, but if life gets in the way, we've got you.

Any time, from your account. If your goals change, message us and we'll adjust your protocol with you. No calls, no retention scripts, no penalty for pausing between cycles.

No insurance — SYNC is cash-pay, which lets us build every protocol around your body rather than around what an insurer will approve. HSA and FSA cards work at checkout like any credit or debit card. Reimbursement depends on your individual plan — if you're unsure, check with your provider or ask your clinician for a Letter of Medical Necessity.

Yes. Buy Now, Pay Later is available on 3-month subscriptions or longer, selectable at checkout. One-time orders and shorter subscriptions are paid upfront.

Your protocol, your body

Stop guessing. Start your protocol.

Five-minute assessment. A licensed clinician builds it. No charge until your protocol is approved.

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Why PT-141

Restored Desire

Supports sexual desire and the wanting to be intimate.

Faster Responsiveness

Supports the body's arousal response and time to arousal.

Non-Hormonal Support

Acts on the nervous system rather than hormones or blood flow.

Emotional Connection

Supports the psychological side of intimacy and confidence with your partner.

Restored Desire

Supports sexual desire and the wanting to be intimate.

Faster Responsiveness

Supports the body's arousal response and time to arousal.

Non-Hormonal Support

Acts on the nervous system rather than hormones or blood flow.

Emotional Connection

Supports the psychological side of intimacy and confidence with your partner.

Restored Desire

Supports sexual desire and the wanting to be intimate.

Faster Responsiveness

Supports the body's arousal response and time to arousal.

Non-Hormonal Support

Acts on the nervous system rather than hormones or blood flow.

Emotional Connection

Supports the psychological side of intimacy and confidence with your partner.

Restored Desire

Supports sexual desire and the wanting to be intimate.

Faster Responsiveness

Supports the body's arousal response and time to arousal.

Non-Hormonal Support

Acts on the nervous system rather than hormones or blood flow.

Emotional Connection

Supports the psychological side of intimacy and confidence with your partner.