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Compounded Semaglutide

Compounded Semaglutide is a GLP-1 medication that mirrors one of the body's own appetite and glucose signals, reducing the constant mental noise around food, supporting fullness after meals, and steadying glucose response over time

Physician-Supervised
Licensed US Compounding Pharmacy
Third-Party Tested
Prescription-Only

Method

$225.00/month

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Charged only after your protocol is approved. Cancel anytime.

Semaglutide is a synthetic version of GLP-1, a hormone the gut releases after eating to signal fullness, slow digestion, and regulate blood sugar.

It works by mimicking that signal for longer than the body's own GLP-1 does — which is why it reduces the constant background pull toward food and steadies how the body responds to meals.

Semaglutide is administered as a once-weekly subcutaneous injection. Protocols start at a low dose and titrate up gradually over the first weeks — your clinician sets the starting dose and the pace of increase based on your intake.

Where your protocol ultimately settles depends on the goal. For some, that's a microdose that provides metabolic support without the fuller weight-loss effect. For others, it's titrating to a full weight-management dose. That's a decision your clinician makes with you at intake and revisits at check-in.

Everything you need to inject at home, in one shipment:

The vial, lyophilized and ready to reconstitute
Bacteriostatic water for reconstitution
Insulin syringes
Alcohol prep pads
Step-by-step reconstitution and injection instructions in your care portal
Sharps disposal guidance

Every prescription is written by a US-licensed clinician after reviewing your intake. It's compounded at a licensed US 503A pharmacy held to cGMP manufacturing standards, and every batch is third-party tested for potency, sterility, pH balance, and endotoxins before it ships. Temperature-controlled from the pharmacy to your door. Full results in the Quality panel below.

Why Compounded Semaglutide

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

How it works

The path to your protocol.

From your intake to your door, every protocol is built by a licensed US clinician around who you are and where you're headed.

Take the assessment.

[01]

Your goals, your body, your history - everything your clinician needs to build a protocol around you.

Clinician-built protocol.

[02]

A US-licensed clinician reviews your intake, selects the right compound, dose and cycle, and approves your protocol within 24 hours.

Delivered. Then evolved.

[03]

Tested every batch. Independently.

Every SYNC protocol is compounded at a licensed US 503A pharmacy and third-party tested — every batch, against four pharmacopoeia standards. If a batch doesn't pass all four, it doesn't ship.

Potency

Passed

Confirms the vial contains what the label says — active ingredient within ±10% of prescribed concentration.

FROM THE COMMUNITY

The ones who stopped guessing

Excellent

"I've never had healthcare feel this frictionless. From the intake to messaging my clinician, everything just works - I ask a question, I get a real answer, and my protocol keeps moving. It's the kind of experience I wish more of healthcare felt like."

Jackson P.Metabolic protocol

"My cycle 2 protocol was genuinely different from cycle 1- the dose had been adjusted and one of the compounds swapped based on how I'd responded. It's the first time I've seen personalization actually happen, not just be marketed."

Chase H.Longevity protocol

"I'd done my research on peptides - the question wasn't whether to take them, it was who to trust. SYNC was the first place where the intake felt like actual medicine. My physician walked me through her reasoning before prescribing anything."

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

The catalog

The architecture of in sync.

Weight

Compounded Tirzepatide

Dual-action weight management, once weekly.

Start your protocol

Weight

Compounded Semaglutide

Appetite, weight and metabolic support.

Start your protocol

Shop all

Learn

From the SYNC journal.

Physician-informed articles on metabolic health, compounded protocols and the research behind them.

Science

The science of GLP-1 & GIP: Understanding metabolic health.

6 min read · Apr 2026

Weight

GLP-1s, explained without the hype: what to actually expect.

8 min read · Mar 2026

Routine

Building a wellness routine that actually sticks past week three.

5 min read · Mar 2026

View all articles

FAQ

Everything worth asking.

Protocols, prescriptions, and what happens after you order.

Contact our care team

Semaglutide engages one of the body's appetite and glucose signals — GLP-1. Tirzepatide engages two — GLP-1 and GIP. Semaglutide has the longest clinical track record of any GLP-1 and a gentler titration curve, which is why it's often the right starting point. Tirzepatide is chosen when the goal calls for a stronger dual-pathway response, or when Semaglutide hasn't delivered what someone was looking for. Your clinician recommends the right one at intake.

Compounded Semaglutide is prescribed for adults working on weight management or metabolic health, in men and women. It's commonly paired with peptides that support recovery, metabolic function, and lean muscle preservation during weight loss — protocols like these help manage the side effect load and support better long-term outcomes.

Your intake goes to a licensed clinician who reviews your medical history, current medications, and goals before writing any prescription. Bloodwork isn't required to start, but your clinician may request labs during the protocol if your intake or check-in flags anything worth confirming.

Appetite regulation returns to baseline over the weeks after the last dose. Some weight regain is common if the underlying eating and training patterns from before the protocol return with it — how much depends on the person. Your clinician can build a taper or maintenance plan at check-in if that's the direction you want to take.

Any time, from your account. If your goals change, message us and we'll adjust your protocol with you. No calls, no retention scripts, no penalty for pausing between cycles.

Message us and we'll expedite a replacement — most reorders ship the same day. Your subscription is timed so this shouldn't happen, but if life gets in the way, we've got you.

No insurance — SYNC is cash-pay, which lets us build every protocol around your body rather than around what an insurer will approve. HSA and FSA support is rolling out soon through our payment partner, and we'll email you when it goes live.

Your protocol, your body

Stop guessing. Start your protocol.

Five-minute assessment. A licensed clinician builds it. No charge until your protocol is approved.

Start your protocol

Compounded Tirzepatide

Compounded Tirzepatide

Compounded Tirzepatide

Compounded Tirzepatide

Compounded Tirzepatide

Compounded Tirzepatide

Compounded Semaglutide

Compounded Semaglutide

Compounded Semaglutide

Why Compounded Semaglutide

Appetite Regulation

Sustainable Weight Management

Reduced Cravings

Steadier Metabolic Response

Appetite Regulation

Sustainable Weight Management

Reduced Cravings

Steadier Metabolic Response

Appetite Regulation

Sustainable Weight Management

Reduced Cravings

Steadier Metabolic Response

Appetite Regulation

Sustainable Weight Management

Reduced Cravings

Steadier Metabolic Response

The path to your protocol.

Take the assessment.

Clinician-built protocol.

Delivered. Then evolved.

Tested every batch. Independently.

Potency

The ones who stopped guessing

The architecture of in sync.

Compounded Tirzepatide

Compounded Semaglutide

From the SYNC journal.

The science of GLP-1 & GIP: Understanding metabolic health.

GLP-1s, explained without the hype: what to actually expect.

Building a wellness routine that actually sticks past week three.

Everything worth asking.

Stop guessing. Start your protocol.

Sterility

pH balance

Endotoxins