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METABOLIC

Compounded Semaglutide

Compounded Semaglutide is a GLP-1 medication that mirrors one of the body's own appetite and glucose signals, reducing the constant mental noise around food, supporting fullness after meals, and steadying glucose response over time. Each vial is compounded with vitamin B12, which supports energy metabolism while appetite and intake shift.

Physician-Supervised
Licensed US Compounding Pharmacy
Third-Party Tested
Prescription-Only

Select a dose.

$161/month

Select a plan

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Charged only after your protocol is approved. Cancel anytime.

Semaglutide is a synthetic version of GLP-1, a hormone the gut releases after eating to signal fullness, slow digestion, and regulate blood sugar.

It works by mimicking that signal for longer than the body's own GLP-1 does — which is why it reduces the constant background pull toward food and steadies how the body responds to meals.

In the SYNC formulation, Semaglutide is compounded with vitamin B12 in the same vial, so it's part of your existing weekly injection. B12 plays a role in energy metabolism and red blood cell formation, and eating less can mean taking in less of it from food.

Semaglutide is administered as a once-weekly subcutaneous injection. Protocols start at a low dose and titrate up gradually over the first weeks — your clinician sets the starting dose and the pace of increase based on your intake.

Where your protocol ultimately settles depends on the goal. For some, that's a microdose that provides metabolic support without the fuller weight-loss effect. For others, it's titrating to a full weight-management dose. That's a decision your clinician makes with you at intake and revisits at check-in.

Everything you need to inject at home, in one shipment:

The vial: Compounded Semaglutide with vitamin B12, lyophilized and ready to reconstitute
Bacteriostatic water for reconstitution
Insulin syringes
Alcohol prep pads
Step-by-step reconstitution and injection instructions in your care portal
Sharps disposal guidance

Every prescription is written by a US-licensed clinician after reviewing your intake. It's compounded at a licensed US 503A pharmacy held to cGMP manufacturing standards, and every batch is third-party tested for potency, sterility, pH balance, and endotoxins before it ships. Temperature-controlled from the pharmacy to your door. Full results in the Quality panel below.

Why Compounded Semaglutide

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

How it works

The path to your protocol.

From your intake to your door, every protocol is built by a licensed US clinician around who you are and where you're headed.

Take the assessment.

[01]

Your goals, your body, your history - everything your clinician needs to build a protocol around you.

Clinician-built protocol.

[02]

A US-licensed clinician reviews your intake, selects the right compound, dose and cycle, and approves your protocol within 24 hours.

Delivered. Then evolved.

[03]

Compounded at a licensed US pharmacy and shipped discreetly. Monthly check-ins keep your clinician close and your protocol evolving with you.

Start your protocol

Tested every batch. Independently.

Every SYNC protocol is compounded at a licensed US 503A pharmacy and third-party tested — every batch, against four pharmacopoeia standards. If a batch doesn't pass all four, it doesn't ship.

Potency

Passed

Confirms the vial contains what the label says — active ingredient within ±10% of prescribed concentration.

Sterility

Passed

Tested against USP 797 to confirm the compound is free from bacterial or fungal contamination.

pH balance

Passed

Balanced to minimize irritation at the injection site and remain compatible with the body.

Endotoxins

Passed

Tested against USP 85 to confirm bacterial endotoxin levels are within safe limits — protecting against fever and adverse reactions.

FROM THE COMMUNITY

The ones who stopped guessing

Excellent

"I've never had healthcare feel this frictionless. From the intake to messaging my clinician, everything just works - I ask a question, I get a real answer, and my protocol keeps moving. It's the kind of experience I wish more of healthcare felt like."

Jackson P.Metabolic protocol

"My cycle 2 protocol was genuinely different from cycle 1- the dose had been adjusted and one of the compounds swapped based on how I'd responded. It's the first time I've seen personalization actually happen, not just be marketed."

Chase H.Longevity protocol

"I'd done my research on peptides - the question wasn't whether to take them, it was who to trust. SYNC was the first place where the intake felt like actual medicine. My physician walked me through her reasoning before prescribing anything."

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

The catalog

The architecture of in sync.

Metabolic

Compounded Tirzepatide

Dual-action weight management, once weekly.

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Metabolic

Compounded Semaglutide

Appetite, weight and metabolic support.

Start your protocol

LONGEVITY

NAD+

Cellular energy and repair support.

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METABOLIC

Tesamorelin

Visceral fat and body composition support.

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HORMONAL

PT-141

Supports desire and arousal response.

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PERFORMANCE

Sermorelin

Recovery, sleep and body composition support.

start your protocol

Shop all

Learn

The SYNC journal.

Physician-informed articles on the compounds, protocols and the research behind them.

SCIENCE

How to get peptides prescribed online: a step-by-step guide.

How to Get Peptides Prescribed Online (2026 Guide)

SAFETY

Are peptides safe? What to know before you start.

Are Peptides Safe? What to Know Before You Start (2026)

HORMONAL

PT-141 (bremelanotide): how it works for men and women.

PT-141 (Bremelanotide): How It Works for Men and Women

View all articles

FAQ

Everything worth asking.

Protocols, prescriptions, and what happens after you order.

Contact our care team

Semaglutide engages one of the body's appetite and glucose signals — GLP-1. Tirzepatide engages two — GLP-1 and GIP. Tirzepatide is chosen when the goal calls for a stronger dual-pathway response, or when Semaglutide hasn't delivered what someone was looking for. Your clinician recommends the right one at intake.

B12 supports energy metabolism and red blood cell formation, and when appetite drops, intake from food can drop with it. Compounding it into the same vial adds that support to your existing weekly injection, so there's no separate supplement and no second injection. If you already take B12 or have a known sensitivity to it, mention it at intake and your clinician will factor it in.

Compounded Semaglutide is prescribed for adults working on weight management or metabolic health, in men and women. It's commonly paired with peptides that support recovery, metabolic function, and lean muscle preservation during weight loss — protocols like these help manage the side effect load and support better long-term outcomes.

Your intake goes to a licensed clinician who reviews your medical history, current medications, and goals before writing any prescription. Bloodwork isn't required to start, but your clinician may request labs during the protocol if your intake or check-in flags anything worth confirming.

Appetite regulation returns to baseline over the weeks after the last dose. Some weight regain is common if the underlying eating and training patterns from before the protocol return with it — how much depends on the person. Your clinician can build a taper or maintenance plan at check-in if that's the direction you want to take.

Any time, from your account. If your goals change, message us and we'll adjust your protocol with you. No calls, no retention scripts, no penalty for pausing between cycles.

Message us and we'll expedite a replacement — most reorders ship the same day. Your subscription is timed so this shouldn't happen, but if life gets in the way, we've got you.

No insurance — SYNC is cash-pay, which lets us build every protocol around your body rather than around what an insurer will approve. HSA and FSA cards work at checkout like any credit or debit card. Reimbursement depends on your individual plan — if you're unsure, check with your provider or ask your clinician for a Letter of Medical Necessity.

Yes. Buy Now, Pay Later is available on 3-month and 6-month subscriptions, selectable at checkout. One-time orders and 1-month subscriptions are paid upfront.

Your protocol, your body

Stop guessing. Start your protocol.

Five-minute assessment. A licensed clinician builds it. No charge until your protocol is approved.

Start your protocol

Why Compounded Semaglutide

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.

Appetite Regulation

Supports appetite control and a stronger sense of fullness.

Sustainable Weight Management

Supports gradual weight loss and long-term weight maintenance.

Reduced Cravings

Supports a calmer mental relationship with hunger and eating.

Steadier Metabolic Response

Steadier blood glucose and insulin response through the day — less post-meal crash, less afternoon slump.