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Metabolic

Tesamorelin

Tesamorelin is a peptide studied for its role in body composition and metabolic health — targeting the visceral fat around the organs, and the metabolic markers tied to it, through the growth hormone pathway rather than through appetite. It's used in protocols for people whose training and weight are already dialled in, but visceral fat and metabolic markers haven't moved with them.

Physician-Supervised
Licensed US Compounding Pharmacy
Third-Party Tested
Prescription-Only

Method

$206/month

Select a plan

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Charged only after your protocol is approved. Cancel anytime.

Tesamorelin is a synthetic GHRH analogue with a stabilising modification that resists breakdown in the bloodstream, letting it stay active longer than the body's own GHRH.

That extended window is what lets it produce sustained shifts in the GH axis, and it's why Tesamorelin has the strongest evidence base of any GHRH analogue for one specific outcome: reduction in visceral fat and improvements in the metabolic markers tied to it.

Tesamorelin is administered as a daily subcutaneous injection, typically taken before bed — timing that aligns with the body's overnight GH release. Your clinician sets your dose and any titration schedule based on your intake.

How the protocol runs from there depends on the goal and how your body responds.

Everything you need to inject at home, in one shipment:

The vial, lyophilized and ready to reconstitute
Bacteriostatic water for reconstitution
Insulin syringes
Alcohol prep pads
Step-by-step reconstitution and injection instructions in your care portal
Sharps disposal guidance

Every prescription is written by a US-licensed clinician after reviewing your intake. It's compounded at a licensed US 503A pharmacy held to cGMP manufacturing standards, and every batch is third-party tested for potency, sterility, pH balance, and endotoxins before it ships. Temperature-controlled from the pharmacy to your door. Full results in the Quality panel below.

Why Tesamorelin

Reduced Visceral Fat

Supports reduction of the metabolically active fat around the organs.

Metabolic Markers

Supports triglycerides, insulin sensitivity, and glucose response.

Lean Mass Preservation

Supports the composition shift toward leaner body composition.

Hepatic Fat

Reduction of fat stored in the liver, and healthy liver markers.

Reduced Visceral Fat

Supports reduction of the metabolically active fat around the organs.

Metabolic Markers

Supports triglycerides, insulin sensitivity, and glucose response.

Lean Mass Preservation

Supports the composition shift toward leaner body composition.

Hepatic Fat

Reduction of fat stored in the liver, and healthy liver markers.

Reduced Visceral Fat

Supports reduction of the metabolically active fat around the organs.

Metabolic Markers

Supports triglycerides, insulin sensitivity, and glucose response.

Lean Mass Preservation

Supports the composition shift toward leaner body composition.

Hepatic Fat

Reduction of fat stored in the liver, and healthy liver markers.

Reduced Visceral Fat

Supports reduction of the metabolically active fat around the organs.

Metabolic Markers

Supports triglycerides, insulin sensitivity, and glucose response.

Lean Mass Preservation

Supports the composition shift toward leaner body composition.

Hepatic Fat

Reduction of fat stored in the liver, and healthy liver markers.

How it works

The path to your protocol.

From your intake to your door, every protocol is built by a licensed US clinician around who you are and where you're headed.

Take the assessment.

[01]

Your goals, your body, your history - everything your clinician needs to build a protocol around you.

Clinician-built protocol.

[02]

A US-licensed clinician reviews your intake, selects the right compound, dose and cycle, and approves your protocol within 24 hours.

Delivered. Then evolved.

[03]

Compounded at a licensed US pharmacy and shipped discreetly. Monthly check-ins keep your clinician close and your protocol evolving with you.

Start your protocol

Tested every batch. Independently.

Every SYNC protocol is compounded at a licensed US 503A pharmacy and third-party tested — every batch, against four pharmacopoeia standards. If a batch doesn't pass all four, it doesn't ship.

Potency

Passed

Confirms the vial contains what the label says — active ingredient within ±10% of prescribed concentration.

Sterility

Passed

Tested against USP 797 to confirm the compound is free from bacterial or fungal contamination.

pH balance

Passed

Balanced to minimise irritation at the injection site and remain compatible with the body.

Endotoxins

Passed

Tested against USP 85 to confirm bacterial endotoxin levels are within safe limits — protecting against fever and adverse reactions.

FROM THE COMMUNITY

The ones who stopped guessing

Excellent

"I've never had healthcare feel this frictionless. From the intake to messaging my clinician, everything just works - I ask a question, I get a real answer, and my protocol keeps moving. It's the kind of experience I wish more of healthcare felt like."

Jackson P.Metabolic protocol

"My cycle 2 protocol was genuinely different from cycle 1- the dose had been adjusted and one of the compounds swapped based on how I'd responded. It's the first time I've seen personalization actually happen, not just be marketed."

Chase H.Longevity protocol

"I'd done my research on peptides - the question wasn't whether to take them, it was who to trust. SYNC was the first place where the intake felt like actual medicine. My physician walked me through her reasoning before prescribing anything."

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

The catalog

The architecture of in sync.

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Compounded Semaglutide

Appetite, weight and metabolic support.

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LONGEVITY

NAD+

Cellular energy and repair support.

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METABOLIC

Tesamorelin

Visceral fat and body composition support.

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HORMONAL

PT-141

Supports desire and arousal response.

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PERFORMANCE

Sermorelin

Recovery, sleep and body composition support.

start your protocol

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Learn

The SYNC journal.

Physician-informed articles on the compounds, protocols and the research behind them.

SCIENCE

How to get peptides prescribed online: a step-by-step guide.

How to Get Peptides Prescribed Online (2026 Guide)

SAFETY

Are peptides safe? What to know before you start.

Are Peptides Safe? What to Know Before You Start (2026)

HORMONAL

PT-141 (bremelanotide): how it works for men and women.

PT-141 (Bremelanotide): How It Works for Men and Women

View all articles

FAQ

Everything worth asking.

Protocols, prescriptions, and what happens after you order.

Contact our care team

Both are GHRH analogues that signal the body's own growth hormone release rather than replacing it. Sermorelin is a shorter-acting compound often used as a general starting point for GH support — sleep, recovery, gradual body composition. Tesamorelin has a longer active window and the strongest evidence base of any GHRH analogue for one specific outcome: reduction in visceral fat and improvements in metabolic markers.

It's typically the right compound when the goal is composition and metabolic-specific rather than general GH support. Your clinician recommends the right one at intake.

Tesamorelin is prescribed for adults working on body composition, visceral fat, or metabolic markers where general approaches haven't fully delivered — in men and women, typically from the mid-30s onward. It's commonly run alongside TRT, HRT, other peptide protocols, or ongoing medication.

Your intake goes to a licensed clinician who reviews your medical history, current medications, and goals before writing any prescription. Baseline IGF-1 and fasting glucose are typically requested before starting Tesamorelin, and repeated at check-ins — this is standard for the compound and part of how your clinician calibrates your protocol and keeps the response within a healthy range.

Tesamorelin works gradually — the response builds over cycles rather than in the first week. Most people notice sleep and recovery changes in the first month. Visceral fat and metabolic marker changes tend to show up in months two and three, confirmed by bloodwork and (if part of your protocol) waist or composition measurements.

Any time, from your account. If your goals change, message us and we'll adjust your protocol with you. No calls, no retention scripts, no penalty for pausing between cycles.

Message us and we'll expedite a replacement — most reorders ship the same day. Your subscription is timed so this shouldn't happen, but if life gets in the way, we've got you.

No insurance — SYNC is cash-pay, which lets us build every protocol around your body rather than around what an insurer will approve. HSA and FSA cards work at checkout like any credit or debit card. Reimbursement depends on your individual plan — if you're unsure, check with your provider or ask your clinician for a Letter of Medical Necessity.

Yes. Buy Now, Pay Later is available on 3-month subscriptions or longer, selectable at checkout. One-time orders and shorter subscriptions are paid upfront.

Your protocol, your body

Stop guessing. Start your protocol.

Five-minute assessment. A licensed clinician builds it. No charge until your protocol is approved.

Start your protocol

Why Tesamorelin

Reduced Visceral Fat

Supports reduction of the metabolically active fat around the organs.

Metabolic Markers

Supports triglycerides, insulin sensitivity, and glucose response.

Lean Mass Preservation

Supports the composition shift toward leaner body composition.

Hepatic Fat

Reduction of fat stored in the liver, and healthy liver markers.

Reduced Visceral Fat

Supports reduction of the metabolically active fat around the organs.

Metabolic Markers

Supports triglycerides, insulin sensitivity, and glucose response.

Lean Mass Preservation

Supports the composition shift toward leaner body composition.

Hepatic Fat

Reduction of fat stored in the liver, and healthy liver markers.

Reduced Visceral Fat

Supports reduction of the metabolically active fat around the organs.

Metabolic Markers

Supports triglycerides, insulin sensitivity, and glucose response.

Lean Mass Preservation

Supports the composition shift toward leaner body composition.

Hepatic Fat

Reduction of fat stored in the liver, and healthy liver markers.

Reduced Visceral Fat

Supports reduction of the metabolically active fat around the organs.

Metabolic Markers

Supports triglycerides, insulin sensitivity, and glucose response.

Lean Mass Preservation

Supports the composition shift toward leaner body composition.

Hepatic Fat

Reduction of fat stored in the liver, and healthy liver markers.