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Metabolic

MOTS-C

MOTS-C is a mitochondrial peptide that acts on the systems regulating how the body produces and uses energy — supporting insulin sensitivity, exercise capacity, and steady metabolic function under daily demand. It works at the cellular energy layer rather than through appetite or hormonal pathways.

Prescribed by board-certified US doctors & clinicians
Active ingredients from FDA-registered facilities
Prescriptions filled by licensed US pharmacies
Guided by your clinician at every step

Injection method

$206/month

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Charged only after your protocol is approved. Cancel anytime.

MOTS-C is a peptide encoded within mitochondrial DNA — one of a small class of molecules the mitochondria produce and release to signal across the body's metabolic system. It acts on muscle, liver, and fat tissue to influence how cells respond to insulin, how energy is used during exercise, and how the body maintains metabolic balance under load.

MOTS-C is administered as a subcutaneous injection, typically two to three times per week. Protocols run in structured cycles — commonly eight to twelve weeks, with many patients extending into six-month arcs to compound the metabolic gains.

Your clinician sets dose, frequency, and cycle length at intake. MOTS-C's mechanism responds directly to physical demand — pairing it with training amplifies the metabolic response.

Everything you need to inject at home, in one shipment:

The vial, lyophilized and ready to reconstitute
Bacteriostatic water for reconstitution
Insulin syringes
Alcohol prep pads
Step-by-step reconstitution and injection instructions in your care portal
Sharps disposal guidance

Every prescription is written by a US-licensed clinician after reviewing your intake. It's compounded at a licensed US 503A pharmacy held to cGMP manufacturing standards, and every batch is third-party tested for potency, sterility, pH balance, and endotoxins before it ships. Temperature-controlled from the pharmacy to your door. Full results in the Quality panel below.

Important Safety Information

Why MOTS-C

Improves Insulin Sensitivity

Helps skeletal muscle absorb glucose more efficiently, supporting blood sugar balance.

Enhances Exercise Capacity

Mimics the metabolic effects of exercise to support endurance, stamina, and how muscle uses energy.

Regulates Metabolism

Acts as a metabolic switch — shifting the body toward burning fat for fuel rather than storing it.

Builds Mitochondrial Capacity

Supports the body's ability to generate new mitochondria, sustaining cellular energy output over time.

Improves Insulin Sensitivity

Helps skeletal muscle absorb glucose more efficiently, supporting blood sugar balance.

Enhances Exercise Capacity

Mimics the metabolic effects of exercise to support endurance, stamina, and how muscle uses energy.

Regulates Metabolism

Acts as a metabolic switch — shifting the body toward burning fat for fuel rather than storing it.

Builds Mitochondrial Capacity

Supports the body's ability to generate new mitochondria, sustaining cellular energy output over time.

Improves Insulin Sensitivity

Helps skeletal muscle absorb glucose more efficiently, supporting blood sugar balance.

Enhances Exercise Capacity

Mimics the metabolic effects of exercise to support endurance, stamina, and how muscle uses energy.

Regulates Metabolism

Acts as a metabolic switch — shifting the body toward burning fat for fuel rather than storing it.

Builds Mitochondrial Capacity

Supports the body's ability to generate new mitochondria, sustaining cellular energy output over time.

Improves Insulin Sensitivity

Helps skeletal muscle absorb glucose more efficiently, supporting blood sugar balance.

Enhances Exercise Capacity

Mimics the metabolic effects of exercise to support endurance, stamina, and how muscle uses energy.

Regulates Metabolism

Acts as a metabolic switch — shifting the body toward burning fat for fuel rather than storing it.

Builds Mitochondrial Capacity

Supports the body's ability to generate new mitochondria, sustaining cellular energy output over time.

How it works

The path to your protocol.

From your intake to your door, every protocol is built by a licensed US clinician around who you are and where you're headed.

Take the assessment.

[01]

Your goals, your body, your history - everything your clinician needs to build a protocol around you.

Clinician-built protocol.

[02]

A US-licensed clinician reviews your intake, selects the right compound, dose and cycle, and approves your protocol within 24 hours.

Delivered. Then evolved.

[03]

Compounded at a licensed US pharmacy and shipped discreetly. Monthly check-ins keep your clinician close and your protocol evolving with you.

Start your protocol

Tested every batch. Independently.

Every SYNC protocol is compounded at a licensed US 503A pharmacy and third-party tested — every batch, against four pharmacopoeia standards. If a batch doesn't pass all four, it doesn't ship.

Potency

Passed

Confirms the vial contains what the label says — active ingredient within ±10% of prescribed concentration.

Sterility

Passed

Tested against USP 797 to confirm the compound is free from bacterial or fungal contamination.

pH balance

Passed

Balanced to minimize irritation at the injection site and remain compatible with the body.

Endotoxins

Passed

Tested against USP 85 to confirm bacterial endotoxin levels are within safe limits — protecting against fever and adverse reactions.

FROM THE COMMUNITY

The ones who stopped guessing

Excellent4

"I've never had healthcare feel this frictionless. From the intake to messaging my clinician, everything just works - I ask a question, I get a real answer, and my protocol keeps moving. It's the kind of experience I wish more of healthcare felt like."

Jackson P.4Metabolic protocol

"My cycle 2 protocol was genuinely different from cycle 1- the dose had been adjusted and one of the compounds swapped based on how I'd responded. It's the first time I've seen personalization actually happen, not just be marketed."

Chase H.Longevity protocol

"I'd done my research on peptides - the question wasn't whether to take them, it was who to trust. SYNC was the first place where the intake felt like actual medicine. My physician walked me through her reasoning before prescribing anything."

Nicki K.verified member

Jackson P.4Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.4Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

Jackson P.4Metabolic protocol

Chase H.Longevity protocol

Nicki K.verified member

The catalog

The architecture of in sync.

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Dual-action weight management, once weekly.

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Appetite, weight and metabolic support.

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METABOLIC

MOTS-C

Mitochondrial and metabolic health support.

Start Your Protocol

METABOLIC

Tesamorelin

Visceral fat and body composition support.

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RECOVERY

BPC-157

Tissue and gut repair support.

start your protocol

RECOVERY

TB-500

Muscle, tendon and ligament recovery support.

Start Your Protocol

LONGEVITY

NAD+

Cellular energy and repair support.

Start Your Protocol

PERFORMANCE

Sermorelin

Recovery, sleep and body composition support.

Start Your Protocol

HORMONAL

PT-141

Supports desire and arousal response.

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Shop all

Learn

The SYNC journal.

Physician-informed articles on the compounds, protocols and the research behind them.

SCIENCE

How to get peptides prescribed online: a step-by-step guide.

How to Get Peptides Prescribed Online (2026 Guide)

SAFETY

Are peptides safe? What to know before you start.

Are Peptides Safe? What to Know Before You Start (2026)

HORMONAL

PT-141 (bremelanotide): how it works for men and women.

PT-141 (Bremelanotide): How It Works for Men and Women

View all articles

FAQ

Everything worth asking.

Protocols, prescriptions, and what happens after you order.

Contact our care team

Both work at the mitochondrial level, but they do different jobs. NAD+ is the coenzyme cells use to produce energy — supplementing it raises the raw material your cells work with. MOTS-C is a signalling peptide that tunes how cells use that energy in the first place, activating the pathways that support insulin sensitivity and fat oxidation. Many patients run both together, with your clinician sequencing the two based on your goals and labs.

Yes. MOTS-C works at the cellular energy layer while GLP-1s work through appetite and glucose regulation — the two pathways complement rather than compete, and pairing them is a common approach for patients running a broader metabolic protocol. Share whatever you're currently on at intake, including semaglutide, tirzepatide, or other metabolic therapies, and your clinician sequences and doses across the full protocol.

Adults working on insulin sensitivity, metabolic function, athletic performance, or long-term energy regulation. It's commonly paired with recovery, performance, and body composition protocols across the SYNC catalogue.

MOTS-C works with the body's own metabolic signalling — no dependence, no downregulation. Gains built during a cycle hold longest for patients who continue training between cycles, which is why we treat MOTS-C as a cyclical protocol tied to real-world work. Many patients return for structured follow-on cycles across the year as part of an ongoing metabolic protocol.

Any time, from your account. If your goals change, message us and we'll adjust your protocol with you. No calls, no retention scripts, no penalty for pausing between cycles.

Message us and we'll expedite a replacement — most reorders ship the same day. Your subscription is timed so this shouldn't happen, but if life gets in the way, we've got you.

No insurance — SYNC is cash-pay, which lets us build every protocol around your body rather than around what an insurer will approve. HSA and FSA cards work at checkout like any credit or debit card. Reimbursement depends on your individual plan — if you're unsure, check with your provider or ask your clinician for a Letter of Medical Necessity.

Yes. Buy Now, Pay Later is available on 3-month subscriptions or longer, selectable at checkout. One-time orders and shorter subscriptions are paid upfront.

Your protocol, your body

Stop guessing. Start your protocol.

Five-minute assessment. A licensed clinician builds it. No charge until your protocol is approved.

Start your protocol

Why MOTS-C

Improves Insulin Sensitivity

Helps skeletal muscle absorb glucose more efficiently, supporting blood sugar balance.

Enhances Exercise Capacity

Mimics the metabolic effects of exercise to support endurance, stamina, and how muscle uses energy.

Regulates Metabolism

Acts as a metabolic switch — shifting the body toward burning fat for fuel rather than storing it.

Builds Mitochondrial Capacity

Supports the body's ability to generate new mitochondria, sustaining cellular energy output over time.

Improves Insulin Sensitivity

Helps skeletal muscle absorb glucose more efficiently, supporting blood sugar balance.

Enhances Exercise Capacity

Mimics the metabolic effects of exercise to support endurance, stamina, and how muscle uses energy.

Regulates Metabolism

Acts as a metabolic switch — shifting the body toward burning fat for fuel rather than storing it.

Builds Mitochondrial Capacity

Supports the body's ability to generate new mitochondria, sustaining cellular energy output over time.

Improves Insulin Sensitivity

Helps skeletal muscle absorb glucose more efficiently, supporting blood sugar balance.

Enhances Exercise Capacity

Mimics the metabolic effects of exercise to support endurance, stamina, and how muscle uses energy.

Regulates Metabolism

Acts as a metabolic switch — shifting the body toward burning fat for fuel rather than storing it.

Builds Mitochondrial Capacity

Supports the body's ability to generate new mitochondria, sustaining cellular energy output over time.

Improves Insulin Sensitivity

Helps skeletal muscle absorb glucose more efficiently, supporting blood sugar balance.

Enhances Exercise Capacity

Mimics the metabolic effects of exercise to support endurance, stamina, and how muscle uses energy.

Regulates Metabolism

Acts as a metabolic switch — shifting the body toward burning fat for fuel rather than storing it.

Builds Mitochondrial Capacity

Supports the body's ability to generate new mitochondria, sustaining cellular energy output over time.